产品货号：
Z36436
中文名称：
RELB抗体
英文名称：
Anti-RELB Antibody (Clone#1684CT450.20.25)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RELB Antibody (Clone#1684CT450.20.25) |
| 指标别名 | I REL;IREL;RELB;Transcription factor RelB |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB |
| 基因名称 | RELB |
| 克隆号 | 1684CT450.20.25 |
| 抗体来源 | Mouse |
| 免疫原 | This RELB antibody is generated from a mouse immunized with a recombinant protein human RELB. |
| 计算分子量 | 62kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation,immunity,differentiation,cell growth,tumorigenesis and apoptosis.NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65,RELB,NFKB1/p105,NFKB1/p50,REL and NFKB2/p52.The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity.Different dimer combinations act as transcriptional activators or repressors,respectively.NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors.NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family.In a conventional activation pathway,I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators,subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus.NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators.RELB neither associates with DNA nor with RELA/p65 or REL.Stimulates promoter activity in the presence of NFKB2/p49.As a member of the NUPR1/RELB/IER3 survival pathway,may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress,such as starvation or gemcitabine treatment.Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner.Increased repression of the heterodimer is seen in the presence of NFKB2/p52. |
| Uniprot ID | Q01201 |
相关搜索：RELB抗体，RELB单抗，Anti-RELB Antibody (Clone#1684CT450.20.25)